Where does Alzheimer's disease begin to affect the brain?

Where does Alzheimer's disease begin to affect the brain?

Gus Alva (Medical Director, ATP Clinical Research) gives expert video advice on: What is "Alzheimer's disease"?; How can I identify the first stage of Alzheimer's disease?; What happens to the brain of an Alzheimer's patient? and more...

The problem begins, as I said, in the basal forebrain. In other words a deep limbic region residing deep in the temporal lobe. In essence what we know about this illness is that both sides of the brain get affected, so there's a bitemporoparietal decrease in, again, the loss of function and volume, which then subsequently migrates over to the frontal portion of the brain, frontal cortices.